Anxiety and the COVID-19 Vaccine

Updated on August 17, 2025
In This Article
Michael LaPick

Written by Michael LaPick

Healthcare Writer

We want to help you make educated healthcare decisions. While this post may have links to lead generation forms, this won’t influence our writing. We adhere to strict editorial standards to provide the most accurate and unbiased information.

Anxiety jumped sharply among Americans at the height of the COVID-19 pandemic. It also dropped quickly once vaccines became widely available. We explored the relationship between rising vaccinations and falling anxiety.

Anxiety jumped sharply

See How the Pandemic Drove Anxiety Levels in Your State

Nationally, anxiety peaked in November 2020. Almost 40% of respondents to the Household Pulse Survey then reported anxiety symptoms in the last seven days.

But anxiety dropped by 26% from January 2021 to April 2021. That coincided with an increase in vaccinations given to Americans from just over four million to more than 200 million doses.

Rising vaccination rates correlate strongly with falling anxiety on a national level. But at the state level it’s not so simple.

A high vaccination rate doesn’t necessarily match one for one with a drop in anxiety. For example, Maine is the most vaccinated state with more than 50% of the population fully vaccinated. But its anxiety level didn’t drop as sharply. Maine had only the ninth highest drop (34.8%) in anxiety between January and April 2021.

Conversely, the state with the greatest drop in anxiety, Wyoming, was one of the least vaccinated (45 out of 50). States where anxiety eased the most like Wyoming (#1), Mississippi (#2) and Utah (#3) tended to be ones with low baseline anxiety that saw large jumps in the pandemic.

On the other hand, some states with high vaccination rates did see large drops in anxiety. The fourth most vaccinated state, Rhode Island saw the fifth largest fall in anxiety (41.6%).

Large states like California, New York, Texas and Florida generally posted lower drops in anxiety in 2021, but had higher overall anxiety levels during the course of the Household Pulse Survey.

State Ranking for Greatest Drop in Anxiety Since Vaccinations Began

State Drop Since January 2021 Pandemic Anxiety Lowest Pandemic Anxiety Highest
Wyoming 51.90% 16.90% 38.80%
Mississippi 50.40% 24.40% 49.20%
Utah 47.50% 20.20% 38.50%
Rhode Island 41.60% 23.00% 41.80%
Virginia 39.90% 22.30% 37.10%
Oklahoma 37.80% 23.50% 44.20%
Delaware 37.20% 21.80% 37.70%
Ohio 36.90% 21.70% 38.10%
Maine 34.80% 22.70% 40.50%
Minnesota 34.70% 20.10% 37.50%
Washington 33.50% 25.20% 41.00%
North Carolina 31.20% 25.90% 39.20%
Idaho 31.20% 22.10% 37.90%
New Hampshire 30.90% 23.30% 37.30%
South Carolina 30.60% 23.70% 37.30%
Arkansas 30.60% 26.10% 40.00%
Illinois 29.50% 25.10% 38.00%
Colorado 29.20% 25.90% 42.20%
Kansas 29.20% 24.00% 40.40%
Hawaii 28.80% 19.60% 37.20%
Pennsylvania 28.30% 24.80% 38.10%
Michigan 27.20% 24.60% 40.70%
Wisconsin 27.10% 21.30% 36.00%
Alaska 26.00% 26.10% 40.30%
United States 25.50% 23.95% 39.63%
Georgia 25.20% 27.10% 40.30%
Oregon 24.50% 24.20% 45.40%
South Dakota 24.00% 20.90% 34.70%
California 23.60% 30.40% 39.90%
Iowa 22.80% 19.00% 41.00%
Connecticut 22.70% 24.70% 38.20%
Tennessee 22.10% 24.80% 40.10%
Nevada 21.50% 27.40% 43.70%
Missouri 20.60% 23.20% 37.80%
New York 20.40% 26.80% 36.60%
Massachusetts 20.10% 25.50% 37.60%
New Jersey 19.30% 26.20% 37.10%
Louisiana 19.30% 27.90% 45.50%
Nebraska 19.20% 21.40% 35.00%
Alabama 19.00% 20.70% 40.10%
Kentucky 19.00% 26.60% 40.20%
New Mexico 18.50% 22.70% 44.70%
Maryland 16.40% 22.80% 36.10%
Vermont 15.00% 23.30% 38.00%
West Virginia 14.40% 26.70% 41.60%
North Dakota 13.30% 18.40% 32.60%
Florida 10.40% 27.60% 39.00%
Arizona 9.60% 25.60% 41.30%
Indiana 9.50% 28.30% 37.70%
District of Columbia 9.30% 23.80% 45.60%
Texas 8.90% 28.80% 42.30%
Montana 5.90% 22.60% 39.90%

Sources: CDC/Census Bureau Household Pulse Survey (anxiety data). OurWorldInData.org (COVID-19 data).

Michael LaPick
About the author

Michael LaPick

Healthcare Writer

Michael LaPick is a healthcare and Medicare data researcher at HealthCare.com, where he develops educational resources for HealthcareInsider.com and MedicareGuide.com. He has over five years of specialized experience researching Medicare, the Affordable Care Act (ACA), and private health insurance, helping consumers make confident, informed coverage decisions.

His work draws on a background in investigative journalism, having reported for the Poughkeepsie Journal and WAMC/NPR Albany on how Americans spend and manage money. This blend of investigative rigor and healthcare expertise gives Michael a unique perspective in translating complex policy data into actionable guidance for readers.

Michael’s research and articles are widely cited across healthcare publications, strengthening his role as a trusted authority in the insurance space.


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